Ferdaus Mohd Altaf Hossain
Ferdaus Mohd Altaf Hossain
Assistant Professor
DVM, MS (Microbiology), MS (Dairy Science), PhD in Immunology (CBNU, SK) Postdoctoral (NIH Fellow), Dept. of Pathology & Microbiology, UNMC, Nebraska, USA
ferdaus.dps@sau.ac.bd

Ferdaus Hossain conducted his Doctoral research on "Immunomodulatory molecules (CCR5, IDO) and signaling pathways of virus-induced exacerbated asthma" through adopting various infectious murine models (Influenza-PR8, Rhinovirus-1B). In this way, he has developed an infectious murine model, and justifying the model validation, in the Dept. of Microbiology, College of Veterinary Medicine, Chonbuk National University, Republic of Korea. He has also basic exposures on immunovirology in detail about JEV, HSV, and Dengue virus using different mice models. Currently, as an NIH fellow, he is working on the Coronavirus immunology using mice models, in the Dept. of Pathology & Microbiology, College of Medicine, University of Nebraska, USA. His ongoing target is to the characterization of the Th responses and mechanisms underlying post Coronavirus secondary (Staphylococcus aureus-MRSA) complications in humans.

Publication Profile:
  • Total publications: 25
  • PubMed (SCI): 8
  • (SCIE): 3
  • SCOPUS/ & Others (12) (Google Scholar's): https://scholar.google.com/citations?hl=en&user=IabgJzEAAAAJ&view_op=list_works&sortby=pubdate
  • Review Articles: 2
  • Proceeding papers: 2
Peer Reviewed Selected Articles:
  • FMA Hossain, SO Park, HJ Kim, et al., (2020). CCR5 attenuates neutrophilic airway inflammation exacerbated by infection with rhinovirus. Cellular Immunology. https://doi.org/10.1016/j.cellimm.2020.1
  • Hossain FMA, Choi JY, Uyangaa E, Park SO, Eo SK (2019). The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation. Immune Netw.19:e30.
  • FMA Hossain, A Anjuman, M Rahman et al. (2019). Characterization of Bacterial Isolates, Antibiogram Profile and Pro-Inflammatory Cytokines in Subclinical Mastitis in Cross-Bred Dairy Cows. Alexandria J Vet Sci., 62 (2): 1-10.
  • J Choi, JH Kim, FMA Hossain, E Uyangaa, SO Park, B Kim, K Kim, SK Eo (2019). Indispensable role of CX3CR1+ dendritic cells in regulation of virus-induced neuroinflammation through rapid development of antiviral immunity in peripheral lymphoid tissues. Frontiers in Immunology, 10, 1467. https://doi.org/10.3389/fimmu.2019.01467.
  • Uyangaa E, Choi JY, Patil AM, Hossain FMA, Park SO, Kim B, Kim K, Eo SK (2018). Dual TLR2/9 Recognition of Herpes Simplex Virus Infection Is Required for Recruitment and Activation of Monocytes and NK Cells and Restriction of Viral Dissemination to the Central Nervous System. Front Immunol. 2018 Apr 30;9:905. doi: 10.3389/fimmu.2018.00905. PMID: 29760708
  • George JA, Kim SB, Choi JY, Patil AM, Hossain FMA, Uyangaa E, Hur J, Park SY, Lee JH, Kim K, Eo SK (2017). TLR2/MyD88 pathway-dependent regulation of dendritic cells by dengue virus promotes antibody-dependent enhancement via Th2-biased immunity. Oncotarget;8(62):106050-106070. doi: 10.18632/oncotarget.22525. PMID: 29285314
  • Choi JY, Kim JH, Patil AM, Kim SB, Uyangaa E, Hossain FMA, Eo SK (2017). Exacerbation of Japanese Encephalitis by CD11chi Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3+ and IL-17+CD4+ Th17 Cells and in Ly-6Chi and Ly-6Clo Monocytes. Immune Netw;17(3):192-200. doi: 10.4110/in.2017.17.3.192. Epub 2017 Jun 20. PMID: 28680381
  • E Zahran, EE Hafez, FMA Hossain, E Mohamed, AA Shaheen (2017). Saprolegniosis in Nile Tilapia: Identification, Molecular Characterization, and Phylogenetic Analysis of Two Novel Pathogenic Saprolegnia Strains. Journal of Aquatic Animal Health, 29 (1), 43-49
  • Md Masudur Rahman, ATM Badruzzaman, Ferdaus Mohd Altaf Hossain, Asmaul Husna, Abusaleh Mahfuzul Bari & Seong Kug Eo (2017). The promise of 4-1BB (CD137) mediated immunomodulation and immunotherapy for viral diseases. FUTURE VIROLOGY VOL. 12, NO. 7 ; https://doi.org/10.2217/fvl-2016-0100.
  • Kim* JH, Hossain* FM, Patil AM, Choi JY, Kim SB, Uyangaa E, Park SY, Lee JH, Kim B, Kim K, Eo SK (2016).Ablation of CD11c(hi) dendritic cells exacerbates Japanese encephalitis by regulating blood-brain barrier permeability and altering tight junction/adhesion molecules. Comp Immunol Microbiol Infect Dis. 2016 Oct;48:22-32. doi: 10.1016/j.cimid.2016.07.007. PMID: 27638116
  • Kim SB, Choi JY, Uyangaa E, Patil AM, Hossain FM, Hur J, Park SY, Lee JH, Kim K, Eo SK (2016). Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses. J Neuroinflammation;13(1):79. doi: 10.1186/s12974-016-0551-5. PMID: 27090635
  • Kim JH, Patil AM, Choi JY, Kim SB, Uyangaa E, Hossain FM, Park SY, Lee JH, Eo SK (2016). CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4(+)Foxp3(+) T and IL-17(+)CD4(+) Th17 cells. J Neuroinflammation;13(1):223. doi: 10.1186/s12974-016-0656-x. PMID: 27439902
  • Kim JH, Patil AM, Choi JY, Kim SB, Uyangaa E, Hossain FM, Park SY, Lee JH, Kim K, Eo SK (2016). CCL2, but not its receptor, is essential to restrict immune privileged central nervous system-invasion of Japanese encephalitis virus via regulating accumulation of CD11b(+) Ly-6C(hi) monocytes. Immunology;149(2):186-203. doi: 10.1111/imm.12626. PMID: 27260136
  • Rahman MM, Noor M, Islam KM, Uddin MB, Hossain FM, Zinnah MA, Al Mamun M, Islam MR, Eo SK, Ashour HM (2015). Molecular diagnosis of bovine tuberculosis in bovine and human samples: implications for zoonosis. Future Microbiol. 10(4):527-35. doi: 10.2217/fmb.14.139. PMID: 25865192
Research Interests:
  • Aero-antigens sensitized canonical allergic asthma revealed with Th2 immune response, whereas, respiratory viruses (like H5N1, RV-1B, RSVs, HSV) induced exacerbation resulting in a typical Th2/Th1/Th17/Th1-Th2/Th1-Th17/Th2-Th17 or even Th9 and Paucigranulocytic responses. Besides, influenza or RVs induced exacerbated asthma (having either Th1 or Th17 signatures) showing very poor or ineffective response to either corticosteroids or other ongoing therapies. Using different infectious murine models, I am interested to focus on mechanistic pathways, and innate-adoptive signaling of Th1, and Th17 phenomena to corroborate the exact characterization of cellular trafficking, cytokine streaming, activation of transcription factors, chemokine and chemokine receptors, tight junctions and adhesion molecules, along with subsequent roles of different inflammasomes, those will provide an effective way to justify new therapeutics. Moreover, post-influenza (H1N1-PR8) methicillin-resistant Staphylococcus aureus (MRSA) co-infection pneumonia models are addressing a new window to study the mechanistic pathways and immunological responses in pediatric patients.
Positions and Affiliations:
  • Assistant Professor, Faculty of Veterinary, Animal & Biomedical Sciences, Sylhet Agricultural University
Awards and Scholarships:
  • NIH (National Institute of Health) Fellow: College of Medicine, UNMC, Nebraska, USA
  • Best International Student (KGSP) Award in 2017 (Ministry of Education, Republic of Korea)
  • NSICT (National Science Information Communication & Technology) Fellowship in the year 2007-2008
  • Dean Award for the scoring topmost CGPA (1st place) in the DVM degree in 2003
  • Awarded as Young Scholar in 2001 by Bangladesh Scholarship Council (BSC) & Nippon Foundation, Japan